PSGL-1 Rabbit pAb - diagbio | 戴格生物

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PSGL-1 Rabbit pAb

db8742

Datasheet

Product Name : PSGL-1 Rabbit pAb

Cat.No.: db8742

Synonyms : CLA; CD162; PSGL1; PSGL-1

Application : WB, IHC, ICC/IF, FC, IP

Reactivity : Human

Host species : Rabbit

Background This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
Immunogen Recombinant protein of human PSGL-1
Gene ID 6404
Swiss Prot Q14242
Synonyms CLA; CD162; PSGL1; PSGL-1
Reactivity Human
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000
IHC: 1:200
ICC/IF: 1:20
FC: 1:100
IP: 1:20
Calculated MW 43 kDa
Observed MW 250 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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