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LRP1 (DGR12006) Rabbit mAb (PBS Only)
db11001-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
- Immunogen A synthetic peptide of human LRP1
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Gene ID
4035
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Swiss Prot
Q07954
- Synonyms APR; KPA; LRP; A2MR; CD91; APOER; LRP1A; TGFBR5; IGFBP3R
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF, FC, IP
- Calculated MW 85 kDa
- Observed MW 85 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12006
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from C6 cells and Rat brain tissue using db11001 at 1:1000. -
Immunohistochemical analysis of paraffin-embedded human Cholangiocarcinoma using db11001 antibody. -
Immunofluorescent analysis of U87-MG cells using db11001 antibody (green), and DAPI (blue). -
Western blot analysis of extracts from HeLa, T24 cells, and Rat heart tissue using db11001 at 1:2000. -
Western blot analysis of extracts from Mouse brain tissue using db11001 at 1:1000. -
Immunofluorescence analysis of HeLa cells labelling LRP1 with db11001.
The cells were fixed with cold 100% methanol (10min, 4℃) and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db11001 (1:100) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 (db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.
Control: Secondary antibody only. -
Immunohistochemical analysis of paraffin-embedded human appendiceal tissue labeling LRP1 with db11001. Counter stained with Hematoxylin. -
Immunohistochemical analysis of paraffin-embedded human placental tissue labeling LRP1 with db11001. Counter stained with Hematoxylin. -
Immunohistochemical analysis of paraffin-embedded mouse uterine tissue labeling LRP1 with db11001. Counter stained with Hematoxylin. -
Immunohistochemical analysis of paraffin-embedded rat renal tissue labeling LRP1 with db11001. Counter stained with Hematoxylin.
订购信息
- Package Price (RMB)
- 10μg 1898
- 100μg 5798
- 货期：现货
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For research use only. Not intended for diagnostic.
