C9orf72 (DGR16164) Rabbit mAb (PBS Only)
Product Name :
C9orf72 (DGR16164) Rabbit mAb (PBS Only)
Cat.No.:
db11289-PBS
Synonyms :
ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016]
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Immunogen
Recombinant protein of human C9orf72
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Gene ID
203228
73205
313155
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Swiss Prot
Q96LT7
Q6DFW0
Q66HC3
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Synonyms
ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1
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Reactivity
Human,Mouse,Rat
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Application
WB
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Recommended dilution
WB: 1:1000
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Calculated MW
54 kDa
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Observed MW
54 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR16164
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/ml
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
5798
- 货期：现货
For research use only. Not intended for diagnostic.
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