C9orf72单克隆抗体(DGR16164) | 高特异性&高亲和力

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Recombinant DGRmAb^®

C9orf72 (DGR16164) Rabbit mAb

db11289

年底大促

Datasheet

Product Name : C9orf72 (DGR16164) Rabbit mAb

Cat.No.: db11289

Synonyms : ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated PBS Only

Background The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016]
Immunogen Recombinant protein of human C9orf72
Gene ID 203228
73205
313155
Swiss Prot Q96LT7
Q6DFW0
Q66HC3
Synonyms ALSFTD; DENND9; FTDALS; DENNL72; FTDALS1
Reactivity Human,Mouse,Rat
Application WB
Recommended dilution WB: 1:1000
Calculated MW 54 kDa
Observed MW 54 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR16164
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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