您当前的位置：
Securin (DGR16413) Rabbit mAb (PBS Only)
db11881-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
- Immunogen A synthetic peptide of human Securin
-
Gene ID
9232
-
Swiss Prot
O95997
- Synonyms EAP1; PTTG; HPTTG; TUTR1
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC
-
Recommended dilution
WB: 1:2000-1:20000
IHC-P: 1:100-1:200
ICC/IF: 1:50
FC: 1:20-1:50 - Calculated MW 22 kDa
- Observed MW 25 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR16413
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
×
![]()
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
