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PHD3 (DGR16500) Rabbit mAb (PBS Only)
db11933-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes.
- Immunogen Recombinant protein of human PHD3
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Gene ID
112399
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Swiss Prot
Q9H6Z9
- Synonyms PHD3; HIFPH3; HIFP4H3
- Reactivity Human,Mouse,Rat
- Application WB, ICC/IF, IP
- Calculated MW 27 kDa
- Observed MW 27 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR16500
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from HeLa cells and Rat spleen tissue using db11933
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
