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Amyloid Precursor Protein (DGR11972) Rabbit mAb (PBS Only)
db12005-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
- Immunogen A synthetic peptide of human Amyloid Precursor Protein
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Gene ID
351
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Swiss Prot
P05067
- Synonyms AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF, IP
- Calculated MW 87 kDa
- Observed MW 100 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR11972
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from 3T3, HeLa cells and Rat brain tissue using db12005 at 1:1000. -
Western blot analysis of extracts from Mouse brain tissue using db12005 at 1:1000. -
Immunohistochemical analysis of paraffin-embedded human brain using db12005 antibody. -
Immunofluorescent analysis of HeLa cells using db12005 antibody (green), and DAPI (blue). -
Immunofluorescence analysis of HeLa cells labelling Amyloid Precursor Protein with db12005.
The cells were fixed with 4% PFA (10min, RT) followed by treatment with 0.1% Triton X-100 (10min, RT), and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db12005 (1:100) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 (db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.
Control: Secondary antibody only.
订购信息
- Package Price (RMB)
- 10μg 1898
- 100μg 5798
- 货期：现货
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For research use only. Not intended for diagnostic.
