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Axin 2 (DGR13699) Rabbit mAb (PBS Only)
db12143-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human Axin 2
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Gene ID
8313
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Swiss Prot
Q9Y2T1
- Synonyms AXIL; ODCRCS
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF
- Calculated MW 94 kDa
- Observed MW 94 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR13699
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of Axin 2 in K562,C6,3T3,Hela cell lysates using Axin 2 antibody(1:1000 diluted).
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
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For research use only. Not intended for diagnostic.
