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TAK1 (DGR14186) Rabbit mAb (PBS Only)
db12332-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
- Immunogen A synthetic peptide of human TAK1
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Gene ID
6885
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Swiss Prot
O43318
- Synonyms CSCF; FMD2; TAK1; MEKK7; TGF1a
- Reactivity Human, Mouse, Rat
- Application WB, IHC, ICC/IF, FC
- Calculated MW 67 kDa
- Observed MW 78 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR14186
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from K562 cells using db12332 at 1:2000. -
Western blot analysis of extracts from K562 cells using db12332 at 1:2000. -
Immunofluorescence analysis of HeLa cells labelling TAK1 with db12332.
The cells were fixed with cold 100% methanol (10min, 4℃) and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db12332 (1:200) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 (db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.
Control: Secondary antibody only.
订购信息
- Package Price (RMB)
- 10μg 1898
- 100μg 5798
- 货期：现货
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For research use only. Not intended for diagnostic.
