TGF beta Receptor II单克隆抗体(DGR33771) | 高特异性&高亲和力

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Recombinant DGRmAb^®

TGF beta Receptor II (DGR33771) Rabbit mAb (PBS Only)

db13044-PBS

Datasheet

Product Name : TGF beta Receptor II (DGR33771) Rabbit mAb (PBS Only)

Cat.No.: db13044-PBS

Synonyms : AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; TGFbeta-RII

Application：

Reactivity : Human

Host species : Rabbit

Un-conjugated PBS Only

Background The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]
Immunogen Recombinant protein of human TGF beta Receptor II
Gene ID 7048
Swiss Prot P37173
Synonyms AAT3; FAA3; LDS2; MFS2; RIIC; LDS1B; LDS2B; TAAD2; TBRII; TBR-ii; TGFR-2; TGFbeta-RII
Reactivity Human
Application ICC/IF, FC
Calculated MW 65 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR33771
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Immunofluorescence analysis of HeLa cells labelling TGF beta Receptor II with db13044.

The cells were fixed with cold 100% methanol (10min, 4℃) and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db13044 (1:500) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 (db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.

Control: Secondary antibody only.

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