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Phospho-c-Met (Tyr1349) (DGR31666) Rabbit mAb (PBS Only)
db13345-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
- Immunogen A synthetic phosphopeptide corresponding to residues surrounding Tyr1349 of human Met
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Gene ID
4233
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Swiss Prot
P08581
- Synonyms HGFR; AUTS9; RCCP2; c-Met; DFNB97
- Reactivity Human
- Application WB, IHC-P, IP
- Calculated MW 156 kDa
- Observed MW 170140 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR31666
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of Met (c-Met) (phospho-Tyr1349) in Hela,A549 cell lysates using Met (c-Met) (phospho-Tyr1349) antibody(1:1000 diluted).
订购信息
- Package Price (RMB)
- 10μg 2598
- 100μg 7858
- 货期：现货
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For research use only. Not intended for diagnostic.
