Glutathione Peroxidase 4 (DGR13808) Rabbit mAb (PBS Only)
Product Name :
Glutathione Peroxidase 4 (DGR13808) Rabbit mAb (PBS Only)
Cat.No.:
db14187-PBS
Synonyms :
GPx-4; PHGPx; snGPx; GSHPx-4; mtPHGPx
Reactivity :
Human, Mouse, Rat
Host species :
Rabbit
Conjugation/Formulation：PBS Only
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Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Disruption of this gene in mouse spermatocytes is associated with male infertility. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes 10 and 17. [provided by RefSeq, Aug 2017]
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Immunogen
A synthetic peptide of mouse Glutathione Peroxidase 4
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Gene ID
625249
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Swiss Prot
O70325
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Synonyms
GPx-4; PHGPx; snGPx; GSHPx-4; mtPHGPx
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Reactivity
Human, Mouse, Rat
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Application
WB, IHC, ICC/IF, FC
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Calculated MW
22 kDa
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Observed MW
22 kDa
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Host species
Rabbit
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Clonality
Monoclonal
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Clonality No.
DGR13808
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Isotype
IgG
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Purity
Affinity Purification
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Conjugation
Un-conjugated
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Concentration
1 mg/mL
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Formulation
PBS Only
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Storage/Stability
Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
订购信息
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Package
Price (RMB)
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100μg
5798
- 货期：现货
For research use only. Not intended for diagnostic.
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