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Cyclin E1 (DGR13531) Rabbit mAb (PBS Only)
db14262-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. [provided by RefSeq, Apr 2016]
- Immunogen A synthetic peptide of human Cyclin E1
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Gene ID
898
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Swiss Prot
P24864
- Synonyms CCNE; pCCNE1
- Reactivity Human
- Application WB, ICC/IF, FC
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Recommended dilution
WB: 1:1000-1:5000
ICC/IF: 1:500-1:1000
FC: 1:100 - Calculated MW 47 kDa
- Observed MW 47 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR13531
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot analysis of extracts from K562, HeLa cells using db14262
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
