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Chk2 (DGR12039) Rabbit mAb (PBS Only)
db14513-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- Immunogen Recombinant protein of human Chk2
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Gene ID
11200
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Swiss Prot
O96017
- Synonyms CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425
- Reactivity Human
- Application WB, IHC-P, ICC/IF, FC, IP
- Calculated MW 61 kDa
- Observed MW 61 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR12039
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/mL
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of Chk2 in Jurkat cell lysates using Chk2 antibody(1:500 diluted). -
Immunofluorescent analysis of HCT116 cells using db14513 antibody (green), and DAPI (blue).
订购信息
- Package Price (RMB)
- 100μg 5798
- 货期：现货
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For research use only. Not intended for diagnostic.
