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cAMP Protein Kinase Catalytic subunit (DGR20464) Rabbit mAb (PBS Only)
db14832-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms. [provided by RefSeq, Jan 2015]
- Immunogen A synthetic peptide of human cAMP Protein Kinase Catalytic subunit
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Gene ID
5566
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Swiss Prot
P17612
- Synonyms PKACA; PPNAD4
- Reactivity Human,Mouse,Rat
- Application WB, IHC-P, ICC/IF, FC, IP
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Recommended dilution
WB: 1:5000-1:50000
IHC-P: 1:200-1:500
ICC/IF: 1:100-1:200
FC: 1:50-1:100
IP: 1:50 - Calculated MW 41 kDa
- Observed MW 41 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR20464
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Western blot detection of cAMP Protein Kinase Catalytic subunit in K562,C6,3T3,Hela cell lysates using cAMP Protein Kinase Catalytic subunit antibody(1:1000 diluted). -
Western blot analysis of extracts from HeLa，MCF-7 cells using db14832
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
相关产品
For research use only. Not intended for diagnostic.
