RIP单克隆抗体(DGR16113) | 高特异性&高亲和力

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Recombinant DGRmAb^®

RIP (DGR16113) Rabbit mAb (PBS Only)

db14919-PBS

Datasheet

Product Name : RIP (DGR16113) Rabbit mAb (PBS Only)

Cat.No.: db14919-PBS

Synonyms : RIP; Rinp; Rip1; D330015H01Rik

Application：

Reactivity : Mouse

Host species : Rabbit

Un-conjugated PBS Only

Background Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules.
Immunogen Recombinant protein of mouse RIP
Gene ID 19766
Swiss Prot Q60855
Synonyms RIP; Rinp; Rip1; D330015H01Rik
Reactivity Mouse
Application WB, ICC/IF, FC, IP
Calculated MW 75 kDa
Observed MW 75 kDa
Host species Rabbit
Clonality Monoclonal
Clonality No. DGR16113
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Concentration 1 mg/mL
Formulation PBS Only
Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.

Western blot analysis of extracts from RAW264.7，3T3 cells using db14919 at 1:1000.

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