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Cofilin (DGR14382) Rabbit mAb (PBS Only)
db15319-PBS
Datasheet
Conjugation/Formulation：PBS Only
- Background The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
- Immunogen A synthetic peptide of human Cofilin
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Gene ID
1072
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Swiss Prot
P23528
- Synonyms CFL; cofilin; HEL-S-15
- Reactivity Human,Mouse,Rat
- Application WB, ICC/IF
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Recommended dilution
WB: 1:1000
ICC/IF: 1:50-1:200 - Calculated MW 19 kDa
- Observed MW 19 kDa
- Host species Rabbit
- Clonality Monoclonal
- Clonality No. DGR14382
- Isotype IgG
- Purity Affinity Purification
- Conjugation Un-conjugated
- Concentration 1 mg/ml
- Formulation PBS Only
- Storage/Stability Store at -20°C. Recommended to aliquot into single-use vials. Supplied in 1X PBS (pH 7.4). BSA and Azide Free. Stable for 12 months from date of receipt.
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Immunofluorescence analysis of HeLa cells labelling Cofilin with db15319.
The cells were fixed with cold 100% methanol (10min, 4℃) and blocked in 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween 20 for 1h. The cells were then incubate with db15319 (1:50) at room temprature for 1h, followed by a further incubation at room temperature for 45min with Goat Anti Rabbit lgG (H+L)-AF488 (db10005, shown in green). Nuclear DNA was labeled in blue with DAPI.
Control: Secondary antibody only.
订购信息
- Package Price (RMB)
- 100μg 4498
- 货期：现货
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For research use only. Not intended for diagnostic.
