Thymidylate Synthase Rabbit pAb - diagbio | 戴格生物

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Thymidylate Synthase Rabbit pAb

db2290

年底大促

Datasheet

Product Name : Thymidylate Synthase Rabbit pAb

Cat.No.: db2290

Synonyms : TS; TMS; HST422

Application：

Reactivity : Human, Mouse, Rat

Host species : Rabbit

Un-conjugated Un-conjugated Un-conjugated Un-conjugated Un-conjugated Un-conjugated Un-conjugated Un-conjugated Un-conjugated

Background Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]
Immunogen A synthetic peptide of human Thymidylate Synthase
Gene ID 7298
Swiss Prot P04818
Synonyms TS; TMS; HST422
Reactivity Human, Mouse, Rat
Application WB, IHC, ICC/IF, FC, IP
Recommended dilution WB: 1:1000-1:5000
IHC: 1:20-1:50
ICC/IF: 1:20-1:50
FC: 1:20
IP: 1:20-1:50
Calculated MW 36 kDa
Observed MW 36 kDa
Host species Rabbit
Clonality Polyclonal
Isotype IgG
Purity Affinity Purification
Conjugation Un-conjugated
Storage/Stability Store at -20°C. Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt.

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