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INSULIN信号通路

发布时间：2024-06-24 02:51:00
胰岛素信号通路对肝脏葡萄糖和脂质代谢的调控至关重要，胰岛素信号通路是指从胰岛素结合到细胞膜上的胰岛素受体，继而激活下游蛋白的磷酸化级联反应，最终产生各种生理效应的一系列过程。在肝脏糖脂代谢方面，胰岛素信号通路的激活一方面刺激肝脏糖酵解和脂肪酸合成，另一方面抑制糖异生和脂肪酸氧化。其中任一环节受损或失调时，就可能扰乱机体的代谢稳态平衡。
胰岛素是控制关键的能量代谢功能如葡糖和脂代谢过程中的主要激素。胰岛素激活胰岛素受体酪氨酸激酶，后者磷酸化并召集不同的底物接头蛋白如IRS家族蛋白。IRS上酪氨酸被磷酸化后成为众多信号传导关联蛋白的结合位点。其中，PI3K在胰岛素功能中起主要的作用，大部分是通过活化Akt/PKB和PKCζ级联来完成的。活化的Akt通过抑制GSK-3诱导糖原的合成，通过mTOR和下游元件影响蛋白合成，通过抑制几个促凋亡分子(Bad，Forkhead家族转录因子，GSK-3)影响细胞生存。胰岛素促进肌肉和脂肪细胞对葡糖的吸收，这是因为它能促使还有GLUT4的囊泡转移到细胞膜上。GLUT4的移位需要PI3K/Akt通路的参与和IR介导的CAP的磷酸化和形成CAP:Cbl:CrkII复合体。胰岛素信号通路也会影响细胞生长和有丝分裂，主要是通过Akt级联进行，也会有Ras/MAPK通路的参与。另外，胰岛素信号通路可以通过中断CREB/CBP/Torc2的结合抑制肝脏中的糖异生。胰岛素信号通路还可以通过激活SREBP-1C，USF1和LXR来促进脂肪酸的合成。从Akt/PKB，PKCζ，p70 S6K和MAPK级联得到的负反馈信息会导致丝氨酸的磷酸化和IRS信号通路的失活。

靶点 产品货号 产品名称 反应种属 应用
4EBP1 db11599 4E BP1 Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
AKT db15719 AKT1 Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,FC,IP
db3626 Phospho-AKT1 (Ser473) Rabbit pAb Human, Mouse, Rat WB, IHC, ICC/IF
db20221 Phospho-AKT1 (Ser124) Rabbit pAb Human, Mouse, Rat WB,IP
db20482 Phospho-AKT1 (Thr450) Rabbit pAb Human, Mouse, Rat WB,IHC,IP
db8405 Phospho-AKT1 (Ser129) Rabbit pAb Human, Mouse, Rat WB
db1727 Phospho-AKT1 (Ser473) Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF
db14851 Phospho-AKT1 (Ser473) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF
db11063 Phospho-AKT1 (Thr450) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,IP
db13907 Phospho-AKT1 (Ser129) Recombinant Rabbit mAb Human, Mouse, Rat WB
db12718 Phospho-AKT1 (Ser124) Recombinant Rabbit mAb Human, Mouse, Rat WB,IP
db11197 Phospho-AKT1 (Ser473) Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF
ATP citrate lyase db3646 ATP citrate lyase Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db6060 ATP Citrate Lyase (3D9) Mouse mAb Human, Mouse, Monkey WB,ICC/IF,FC
db11738 ATP Citrate lyase Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP
db8509 Phospho-ATP citrate lyase (Thr447/Ser451) Rabbit pAb Human, Mouse, Rat WB,ICC/IF,IP
db14234 Phospho-ATP citrate lyase (Thr447/Ser451) Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,IP
BAD db915 Bad Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db11004 Bad Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP
db21725 Phospho-Bad (Ser112) Rabbit pAb Human, Mouse, Rat WB,IP
db12648 Phospho-Bad (Ser112) Recombinant Rabbit mAb Human, Mouse, Rat WB,IP
CRK db6158 CRK (3H7) Mouse mAb Human WB
db20993 Phospho-Crk p38 (Tyr221) Rabbit pAb Human WB,ICC/IF
db12681 Phospho-Crk p38 (Tyr221) Recombinant Rabbit mAb Human WB,ICC/IF
EIF4B db22375 eIF4B Rabbit pAb Human WB,IHC,ICC/IF,FC
db13058 eIF4B Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC
db21516 Phospho-eIF4B (Ser406) Rabbit pAb Human, Mouse, Rat WB,IHC
db14066 Phospho-eIF4B (Ser406) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC
Flotillin 1 db3547 Flotillin 1 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db1730 Flotillin 1 Rabbit pAb Human, Mouse WB
db6473 Flotillin 1 (6H9) Mouse mAb Mouse, Rat WB
db14784 Flotillin 1 Recombinant Rabbit mAb Human, Mouse WB
db11731 Flotillin 1 Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP
Flotillin 2 db8678 Flotillin 2 Rabbit pAb Human, Mouse, Rat WB,IP
db14444 Flotillin 2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IP
GAB2 db22287 GAB2 Rabbit pAb Human, Mouse, Rat WB,ICC/IF
db20792 GAB2 Rabbit pAb Human, Mouse, Rat WB,ICC/IF,FC
db13625 GAB2 Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,FC
db13166 GAB2 Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
GRB2 db2356 GRB2 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db2344 GRB2 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db6102 GRB2 (5G3) Mouse mAb Human, Mouse, Rat WB
db15571 GRB2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db15565 GRB2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
GSK3B db6410 GSK3 beta Mouse mAb Human, Mouse, Rat WB,IHC-P,FC
db2634 GSK3 beta Rabbit pAb Human, Mouse WB,IHC,ICC/IF,FC
db6073 GSK3 beta (2E6) Mouse mAb Human, Mouse, Rat WB,ICC/IF,IP,FC
db6551 GSK3 beta (4C4) Mouse mAb Human, Rat, Mouse WB,IHC-P
db6550 GSK3 beta (9B1) Mouse mAb Human, Rat, Mouse WB,IHC-P
db6549 GSK3 beta (9F9) Mouse mAb Human, Rat, Mouse WB,IHC-P
db14808 GSK3 beta Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,FC
db1715 Phospho-GSK3 beta (Ser9) Rabbit pAb Human WB,IHC,ICC/IF
db13257 Phospho-GSK3 beta (Ser9) Recombinant Rabbit mAb Human WB,IHC,ICC/IF
Insulin db412 Insulin Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF
db20504 Insulin Rabbit pAb Human IHC
db1813 Insulin Rabbit pAb Human WB,IHC
db30132 Insulin Recombinant Mouse mAb Human IHC
db13712 Insulin Recombinant Rabbit mAb Human IHC
db15695 Insulin Recombinant Rabbit mAb Human WB,IHC
db12456 Insulin Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF
IRS1 db2497 IRS1 Rabbit pAb Human WB,IHC,ICC/IF,FC
db15530 IRS1 Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC
db2330 Phospho-IRS1 (Tyr632) Rabbit pAb Human WB
db14020 Phospho-IRS1 (Tyr632) Recombinant Rabbit mAb Human WB
JNK db8572 JNK1 Rabbit pAb Human, Mouse, Rat WB
db58 JNK1 Rabbit pAb Human, Mouse, Rat WB
db6223 JNK1 (1A4) Mouse mAb Human, Mouse, Rat WB,ICC/IF
db13511 JNK1 Recombinant Rabbit mAb Human, Mouse, Rat WB
db12544 JNK1 Recombinant Rabbit mAb Human, Mouse, Rat WB
db20141 Phospho-JNK1 (Thr183/Tyr185) Rabbit pAb Human WB,IP
db11220 Phospho-JNK1 (Thr183/Tyr185) Recombinant Rabbit mAb Human WB,IP
JNK2 db13968 JNK2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,FC,IP
db3780 JNK2 Rabbit pAb Human, Mouse, Rat WB,IHC,FC,IP
MTOR db8578 mTOR Rabbit pAb Human, Mouse, Rat WB
db2001 mTOR Rabbit pAb Human, Mouse, Rat WB,IHC,IP
db15657 mTOR Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,IP
db14469 mTOR Recombinant Rabbit mAb Human, Mouse, Rat WB
db7351 Phospho-mTOR (Ser2448) Rabbit pAb Human, Mouse WB,IHC
db2436 Phospho-mTOR (Ser2481) Rabbit pAb Human, Mouse, Rat WB
db11887 Phospho-mTOR (Ser2448) Recombinant Rabbit mAb Human, Mouse WB, IHC
db14018 Phospho-mTOR (Ser2481) Recombinant Rabbit mAb Human, Mouse, Rat WB
p70 S6K db3819 P70 S6 Kinase beta Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db332 P70 S6 Kinase alpha Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db14017 P70 S6 Kinase beta Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db12587 P70 S6 Kinase alpha Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db2418 Phospho-P70 S6 Kinase beta (Ser371) Rabbit pAb Human, Mouse, Rat WB
db14307 Phospho-P70 S6 Kinase beta (Ser371) Recombinant Rabbit mAb Human, Mouse, Rat WB
PDK2 db841 PDK2 Rabbit pAb Human, Mouse, Rat WB,IHC,IP
db14302 PDK2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,IP
PI3K p110 db1678 PI3-Kinase p110 beta Rabbit pAb Human WB,FC,IP
db3038 PI3-Kinase p110 beta Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db2282 PI3-Kinase p110 delta Rabbit pAb Human, Mouse, Rat WB,ICC/IF
db1652 PI3-Kinase p110 delta Rabbit pAb Human WB,ICC/IF,IP
db11128 PI3-Kinase p110 beta Recombinant Rabbit mAb Human WB, FC, IP
db15409 PI3-Kinase p110 beta Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db15724 PI3-Kinase p110 delta Recombinant Rabbit mAb Human WB,ICC/IF,IP
db15594 PI3-Kinase p110 delta Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
PKC alpha db2373 PKC alpha Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db13040 PKC alpha Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db23744 Phospho-PKC alpha (Thr497) Rabbit pAb Human, Mouse, Rat WB, IHC
db1662 Phospho-PKC alpha (Thr638) Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db20232 Phospho-PKC alpha (Ser657) Rabbit pAb Human, Mouse, Rat WB,IHC
db11446 Phospho-PKC alpha (Ser657) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC
db11122 Phospho-PKC alpha (Thr638) Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, IP
db11402 Phospho-PKC alpha (Thr497) Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC
PKC zeta db4725 Phospho-PKC zeta (Thr560) Rabbit pAb Human, Mouse, Rat WB
db13941 Phospho-PKC zeta (Thr560) Recombinant Rabbit mAb Human, Mouse, Rat WB
db21023 Phospho-PKC zeta/lambda (Thr410/Thr412) Rabbit pAb Human, Mouse, Rat WB,IHC
db13764 Phospho-PKC zeta/lambda (Thr410/Thr412) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC
PPP1CB db6655 PP1C alpha Mouse mAb Human, Mouse, Rat, Monkey WB,ICC/IF
db6650 PP1C alpha Mouse mAb Human WB,IHC-F,IHC-P,ICC/IF
db21921 PP1C alpha/beta Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db6069 PP1C alpha (1H1) Mouse mAb Human WB,ICC/IF
db6027 PP1C alpha (1C11) Mouse mAb Human WB,IHC-F,IHC-P,ICC/IF
db6068 PP1C gamma (2F2A3) Mouse mAb Human WB
db12099 PP1C alpha/beta Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
PTEN db3274 PTEN Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db21985 PTEN Rabbit pAb Human, Mouse, Rat WB,IHC,FC,IP
db8911 PTEN Rabbit pAb Human, Mouse, Rat WB
db3424 PTEN Rabbit pAb Human, Mouse, Rat WB
db986 PTEN Rabbit pAb Human, Mouse, Rat WB
db6563 PTEN (7H2) Mouse mAb Human IHC-P
db14281 PTEN Recombinant Rabbit mAb Human, Mouse, Rat WB
db15824 PTEN Recombinant Rabbit mAb Human, Mouse, Rat WB
db14380 PTEN Recombinant Rabbit mAb Human, Mouse, Rat WB
db12505 PTEN Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db13256 PTEN Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,FC,IP
db4130 Phospho-PTEN (Ser380) Rabbit pAb Human, Mouse, Rat WB,ICC/IF
db13955 Phospho-PTEN (Ser380) Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
Raptor db1233 Raptor Rabbit pAb Human, Mouse, Rat WB,IHC
db15779 Raptor Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC
SHP2 db20952 SHP2 Rabbit pAb Mouse, Rat WB, IP
db445 SHP2 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db8194 SHP2 Rabbit pAb Human, Mouse, Rat WB,IP
db11960 SHP2 Recombinant Rabbit mAb Human WB, IHC, ICC/IF, FC, IP
db14530 SHP2 Recombinant Rabbit mAb Human, Mouse, Rat WB,IP
db11774 SHP2 Recombinant Rabbit mAb Mouse, Rat WB, IP
db3351 Phospho-SHP2 (Tyr542) Rabbit pAb Human, Mouse WB,ICC/IF,IP
db1232 Phospho-SHP2 (Tyr582) Rabbit pAb Human WB
db14096 Phospho-SHP2 (Tyr582) Recombinant Rabbit mAb Human WB
db13976 Phospho-SHP2 (Tyr542) Recombinant Rabbit mAb Human, Mouse WB,ICC/IF,IP
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