研究领域 Research field
缺氧信号转导

细胞缺氧条件下

在氧气浓度较低时,脯氨酸羟化酶(PHD)没有氧气作为底物,导致HIF-α泛素化无法进行,细胞内的泛素化酶(VHL)无法识别未泛素化的HIF-α进行降解,则导致HIF-α聚集在细胞内。聚集的HIF-α与HIF-β结合,形成有启动转录活性的HIF复合物。在细胞核中,HIF复合物与缺氧反应基因启动子区上的缺氧反应元件(HRE)结合,募集其他转录因子,激发下游的基因的表达。同时,质膜上的多种受体就会通过各种信号通路,上调HIF-α水平,促进缺氧相关基因表达。

靶点 产品货号 产品名称 反应种属 应用
HIF db12445 HIF-1-alpha Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
db12576 HIF-1-alpha Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
db15943 HIF-2-alpha Recombinant Rabbit mAb Human WB,IHC
db12161 HIF1 beta Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,FC
db526 HIF-2-alpha Rabbit pAb Human WB,IHC
db794 HIF-1-alpha Rabbit pAb Human, Mouse, Rat WB,ICC/IF
db489 HIF-1-alpha Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db22517 HIF1 beta Rabbit pAb Human, Mouse, Rat WB,IHC,FC
PIK3K db15064 PI3-Kinase p85 beta Recombinant Rabbit mAb Human, Rat WB,IHC,ICC/IF,IP
db16082 PI3-Kinase p85 alpha Recombinant Rabbit mAb Human, Mouse, Rat IHC,ICC/IF,FC
db15622 PI3-Kinase p85 alpha Recombinant Rabbit mAb Human, Mouse, Rat WB
db12183 PI3-Kinase p85 alpha Recombinant Rabbit mAb Human, Mouse, Rat WB
db13949 PI3-Kinase p85 alpha Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,FC,IP
db6187 PI3-Kinase p85 beta (8D9) Mouse mAb Human, Mouse, Rat WB
db6610 PI3-Kinase p85 alpha (3H5) Mouse mAb Human, Mouse, Rat WB,IHC-P
db6611 PI3-Kinase p85 alpha (1C8) Mouse mAb Human, Mouse, Rat WB,IHC-P
db951 PI3-Kinase p85 alpha Rabbit pAb Human, Mouse, Rat WB,ICC/IF,FC,IP
db2115 PI3-Kinase p85 alpha Rabbit pAb Human, Mouse, Rat WB
db4301 PI3-Kinase p85 beta Rabbit pAb Human, Rat WB,IHC,ICC/IF,FC,IP
db20528 PI3-Kinase p85 alpha Rabbit pAb Human, Mouse, Rat WB
db15409 PI3-Kinase p110 beta Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db15594 PI3-Kinase p110 delta Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
db15724 PI3-Kinase p110 delta Recombinant Rabbit mAb Human WB,ICC/IF,IP
db11128 PI3-Kinase p110 beta Recombinant Rabbit mAb Human WB, FC, IP
db1652 PI3-Kinase p110 delta Rabbit pAb Human WB,ICC/IF,IP
db2282 PI3-Kinase p110 delta Rabbit pAb Human, Mouse, Rat WB,ICC/IF
db3038 PI3-Kinase p110 beta Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC
db1678 PI3-Kinase p110 beta Rabbit pAb Human WB,FC,IP
AKT db15734 AKT1/2/3 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db11977 AKT1/2/3 Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC, IP
db14689 AKT1/2/3 Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF
db6565 AKT1/2/3 (2A1) Mouse mAb Human, Rat, Mouse IHC-P
db6344 AKT1/2/3 Mouse mAb Human, Mouse, Rat WB,IP
db1607 AKT1/2/3 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
db5830 AKT1/2/3 Rabbit pAb Human, Mouse, Rat WB,ICC/IF
db5728 AKT1/2/3 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,FC,IP
mTOR db11887 Phospho-mTOR (Ser2448) Recombinant Rabbit mAb Human, Mouse WB, IHC
db14018 Phospho-mTOR (Ser2481) Recombinant Rabbit mAb Human, Mouse, Rat WB
db2436 Phospho-mTOR (Ser2481) Rabbit pAb Human, Mouse, Rat WB
db7351 Phospho-mTOR (Ser2448) Rabbit pAb Human, Mouse WB,IHC
db14469 mTOR Recombinant Rabbit mAb Human, Mouse, Rat WB
db15657 mTOR Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,IP
db2001 mTOR Rabbit pAb Human, Mouse, Rat WB,IHC,IP
db8578 mTOR Rabbit pAb Human, Mouse, Rat WB
JAK-STAT db2764 Phospho-JAK1 (Tyr1022/Tyr1023) Rabbit pAb Human WB,IHC
db1627 Phospho-JAK2 (Tyr1007/Tyr1008) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db14880 JAK2 Recombinant Rabbit mAb Human,Mouse,Rat WB,ICC/IF
db6132 JAK1 (7B1) Mouse mAb Human,Rat WB,IP
db6133 JAK1 (8B8) Mouse mAb Human,Mouse WB,ICC/IF,IP
db6630 JAK1 (8D8) Mouse mAb Human,Mouse,Rat IHC-P
db6223 JNK1 (1A4) Mouse mAb Human,Monkey WB,ICC/IF
db6585 JAK2 (6B4) Mouse mAb Human,Mouse,Rat IHC-P
db6584 JAK2 (7H5) Mouse mAb Human,Mouse,Rat IHC-P
db9826 JAK1 Rabbit pAb Human,Mouse,Rat WB
db3405 JAK2 Rabbit pAb Human,Mouse,Rat WB,ICC/IF
db6555 Phospho-STAT3 (Tyr705) (5E9) Mouse mAb Human IHC-P
db2704 Phospho-STAT3 (Ser727) Rabbit pAb Human,Rat WB,IHC,ICC/IF
db12152 Phospho-STAT3 (Ser727) Recombinant Rabbit mAb Human,Rat WB,IHC,ICC/IF
db2536 Phospho-STAT3 (Tyr705) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db12896 STAT3 Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC,IP
db6609 STAT3 (6H10) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6208 STAT3 (4C8) Mouse mAb Human,Mouse,Rat WB
db7769 STAT3 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
db1086 STAT3 Rabbit pAb Human WB,IHC,ICC/IF,FC,IP
db1650 STAT3 Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC
NF-κB db6589 Acetyl-NF-kB p65 (Lys314/Lys315) (5F4) Mouse mAb Human,Mouse,Rat IHC-P
db6590 Acetyl-NF-kB p65 (Lys314/Lys315) (6D6) Mouse mAb Human,Mouse,Rat IHC-P
db3028 Phospho-NF-kB p65 (Ser276) Rabbit pAb Human WB,ICC/IF,IP
db508 Phospho-NF-kB p65 (Ser311) Rabbit pAb Human WB
db7996 Phospho-NF-kB p65 (Ser536) Rabbit pAb Human WB,IP
db13524 NF-kB p65 Recombinant Rabbit mAb Human WB,ICC/IF,FC
db11612 NF-kB p65 Recombinant Rabbit mAb Human, Mouse WB,IHC,ICC/IF,FC,IP
db6428 NF-kB p65 (5A10) Mouse mAb Human,Mouse,Rat WB,IHC-P,IP
db6456 NF-kB p65 (3D2) Mouse mAb Human,Mouse,Rat WB,IHC-F,IHC-P,ICC/IF,IP
db8358 NF-kB p65 Rabbit pAb Human WB,ICC/IF,FC
db3141 NF-kB p65 Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC,IP
eIF4E  db11218 Phospho-eIF4E (Ser209) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db8101 Phospho-eIF4E (Ser209) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db13610 eIF4E Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db11590 eIF4E Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,FC,IP
db6264 eIF4E (8C8) Mouse mAb Human,Mouse,Rat WB
db5468 eIF4E Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,FC,IP
db7770 eIF4E Rabbit pAb Human,Mouse,Rat WB,IHC,FC,IP

 

细胞正常氧气条件下

细胞在氧气含量正常的情况下,HIF-α在依赖于氧气的PHD的脯氨酸残基上羟基化和依赖于氧气的HIF1AN的天冬氨酸残基上羟基化。羟基化的HIF-α与VHL肿瘤抑制蛋白(pVHL),将HIF-α进行降解,从而减少HIF-α浓度。此外,在不缺氧气的情况下,HIF-α还会被其他物质抑制转录活性,阻断缺氧信号的传递。

靶点 产品货号 产品名称 反应种属 应用
PHD db11933 PHD3 Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db11394 PHD1 Recombinant Rabbit mAb Human, Mouse, Rat WB, IHC, ICC/IF, FC
db5389 PHD3 Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db4737 PHD1 Rabbit pAb Human, Mouse, Rat WB, IHC, ICC/IF, FC
FIH db13431 HIF1AN Recombinant Rabbit mAb Human WB,IHC,ICC/IF,FC
db21250 HIF1AN/FIH-1 Rabbit pAb Human,Mouse,Rat WB,FC
GSK-3β db2986 Phospho-GSK3 (alpha/beta) (Tyr216/Tyr279) Rabbit pAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db13049 Phospho-GSK3 (alpha/beta) (Tyr216/Tyr279) Recombinant Rabbit mAb Human,Mouse,Rat WB,IHC,ICC/IF,IP
db2953 GSK3 (alpha/beta) Rabbit pAb Human,Mouse,Rat WB
db14079 GSK3 (alpha/beta) Recombinant Rabbit mAb Human,Mouse,Rat WB
db6073 GSK3 beta (2E6) Mouse mAb Human,Mouse,Rat WB,ICC/IF,IP,FC
db6551 GSK3 beta (4C4) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6550 GSK3 beta (9B1) Mouse mAb Human,Mouse,Rat WB,IHC-P
db6549 GSK3 beta (9F9) Mouse mAb Human,Mouse,Rat WB,IHC-P
db1715 Phospho-GSK3 beta (Ser9) Rabbit pAb Human WB,IHC,ICC/IF
db13257 Phospho-GSK3 beta (Ser9) Recombinant Rabbit mAb Human WB,IHC,ICC/IF
db6410 GSK3 beta Mouse mAb Human,Mouse WB,IHC-P,FC
db2634 GSK3 beta Rabbit pAb Human,Mouse WB,IHC,ICC/IF,FC
db14808 GSK3 beta Recombinant Rabbit mAb Human,Mouse WB,IHC,ICC/IF,FC
β-catenin db12676 Phospho-beta Catenin (Thr41/Ser45) Recombinant Rabbit mAb Human WB,IP
db12691 Phospho-beta Catenin (Ser37) Recombinant Rabbit mAb Human, Mouse, Rat WB
db21020 Phospho-beta Catenin (Thr41/Ser45) Rabbit pAb Human WB,IP
db20715 Phospho-beta Catenin (Ser37) Rabbit pAb Human, Mouse, Rat WB
db11055 beta Catenin Recombinant Rabbit mAb Human, Mouse, Rat WB,ICC/IF,FC
db13925 beta Catenin Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db6360 beta Catenin (5D6) Mouse mAb Human, Mouse, Rat WB
db1772 beta Catenin Rabbit pAb Human, Mouse, Rat WB,IHC,ICC/IF,IP
db2829 beta Catenin Rabbit pAb Human, Mouse, Rat WB,ICC/IF,FC
p53 db2601 Acetyl-p53 (Lys305) Rabbit pAb Human, Mouse, Rat WB
db11373 Acetyl-p53 (Lys305) Recombinant Rabbit mAb Human, Mouse, Rat WB
db8261 Acetyl-p53 (Lys370) Rabbit pAb Human, Mouse, Rat WB,ICC/IF,FC,IP
db11223 Acetyl-p53 (Lys370) Recombinant Rabbit mAb Human, Mouse, Rat WB, ICC/IF, FC, IP
db3896 Acetyl-p53 (Lys373) Rabbit pAb Human WB, IHC, ICC/IF, FC
db11868 Acetyl-p53 (Lys373) Recombinant Rabbit mAb Human WB, IHC, ICC/IF, FC
db6593 Acetyl-p53 (Lys382) (2G4) Mouse mAb Human, Rat, Mouse IHC-P
db6592 Acetyl-p53 (Lys382) (3E3) Mouse mAb Human, Rat, Mouse IHC-P
db6591 Acetyl-p53 (Lys382) (7E1) Mouse mAb Human, Rat, Mouse IHC-P
db1766 Acetyl-p53 (Lys382) Rabbit pAb Human WB,ICC/IF,FC
db12608 Acetyl-p53 (Lys382) Recombinant Rabbit mAb Human WB,ICC/IF,FC
db488 p53 Rabbit pAb Human WB,ICC/IF
db3246 p53 Rabbit pAb Human WB,IHC,ICC/IF
db9894 p53 Rabbit pAb Mouse WB,ICC/IF,FC,IP
db9370 p53 Rabbit pAb Human, Mouse WB, ICC/IF, FC, IP
db2806 p53 Rabbit pAb Human WB, IHC, ICC/IF, FC, IP
db30148 p53 Recombinant Mouse mAb Human IHC
db14679 p53 Recombinant Rabbit mAb Mouse WB,ICC/IF,FC,IP
db11669 p53 Recombinant Rabbit mAb Human WB, IHC, ICC/IF, FC, IP
db11663 p53 Recombinant Rabbit mAb Human, Mouse WB, ICC/IF, FC, IP
db15330 p53 Recombinant Rabbit mAb Human WB,IHC,ICC/IF
db12023 p53 Recombinant Rabbit mAb Human WB,ICC/IF
db5327 Phospho-p53 (Ser15) Rabbit pAb Human WB,IHC,ICC/IF,IP
db13928 Phospho-p53 (Ser15) Recombinant Rabbit mAb Human WB,IHC,ICC/IF,IP
db3404 Phospho-p53 (Ser37) Rabbit pAb Human WB
db13975 Phospho-p53 (Ser37) Recombinant Rabbit mAb Human WB
db21514 Phospho-p53 (Ser376) Rabbit pAb Human WB
db12653 Phospho-p53 (Ser376) Recombinant Rabbit mAb Human WB
db33 Phospho-p53 (Ser392) Rabbit pAb Human WB,IHC,ICC/IF,IP
db6 Phospho-p53 (Ser392) Rabbit pAb Human, Mouse, Rat WB,IHC,IP
db12599 Phospho-p53 (Ser392) Recombinant Rabbit mAb Human, Mouse, Rat WB,IHC,IP
db14129 Phospho-p53 (Ser392) Recombinant Rabbit mAb Human WB,IHC,ICC/IF,IP
db2581 Phospho-p53 (Ser46) Rabbit pAb Human WB,IHC,ICC/IF,IP
db14012 Phospho-p53 (Ser46) Recombinant Rabbit mAb Human WB,IHC,ICC/IF,IP
db20824 Phospho-p53 (Ser6) Rabbit pAb Human WB,IHC,IP
db11095 Phospho-p53 (Ser6) Recombinant Rabbit mAb Human WB,IHC,IP
db21129 Phospho-p53 (Thr55) Rabbit pAb Human WB
db12668 Phospho-p53 (Thr55) Recombinant Rabbit mAb Human WB